THRX-144644

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THRX-144644

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2442519-59-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

THRX-144644 是一种肺限制性ALK5抑制剂，其IC₅₀值为 0.14 nM。THRX-144644 避免了与 TGFβ 途径抑制相关的全身毒性。

生物活性

THRX-144644 is a Lung-restrictedALK5inhibitor with anIC₅₀value of 0.14 nM. THRX-144644 avoids systemic toxicities associated with TGFβ pathway inhibition^[1].

IC₅₀& Target^[1]

ALK5

0.14 nM (IC₅₀)

体外研究
(In Vitro)

THRX-144644 (1-10000 nM; 1 h) inhibits ALK5 with an IC₅₀value of 23 nM in human BEAS2B cell line.

体内研究
(In Vivo)

THRX-144644 (2-60 mg/kg; Inhalation: nebulizer, daily, for 14 days) is a Lung-selective inhibitor and targets to the lungs in Sprague Dawley rats^[1].

Animal Model:	Sprague Dawley rats^[1]
Dosage:	2, 10, and 60 mg/kg
Administration:	Inhalation: nebulizer, daily, for 14 days
Result:	Had the L:P ratio (AUC) was 0.44. Had lung-to-plasma ratios ranged from 100- to 1200-fold in rats across dose level. Had lung trough (24 h) concentrations in rats ranged from 3- to 17-fold above the PCLS IC50 across tolerated doses.

分子量

512.00

Formula

C₂₆H₂₈ClF₂N₇

CAS 号

2442519-59-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.