SY-LB-57 是一种高效的骨形态发生蛋白 (BMP) 受体信号传导激动剂，可用于骨折和肺动脉高压等疾病的研究。
| 生物活性 | SY-LB-57 is a highly potentbone morphogenetic protein(BMP) receptor signaling agonist. SY-LB-57 can be used in studies of diseases such as fractures and pulmonary arterial hypertension[1]. |
体外研究
(In Vitro) | SY-LB-57 (0.01-1000 μM, 24 h) can significantly induce cell proliferation at concentrations below 10 μM with an IC50value of 807.93 μM in C2C12 cells[1].
SY-LB-57 (0.01-10 μM, 15-30 min) increases the phosphorylation of Smad protein and promotes p-Smad nuclear translocation while activates the PI3K/Akt pathway and induces cytoplasmic localization of p-Akt[1].
SY-LB-57 (0.01-10 μM, 24 h) can induce cell cycle shift towards proliferation[1].
Cell Viability Assay[1] | Cell Line: | C2C12 cells | | Concentration: | 0.01-1000 μM | | Incubation Time: | 24 hours | | Result: | Resulted in 85% reduction in the cell viability of C2C12 at 1 mM while increased cell viability by 280%, 290%, 200%, 150% and 50% at 0.01 μM, 0.1 μM, 1 μM, 10 μM and 100 μM, respectively. |
Western Blot Analysis[1] | Cell Line: | C2C12 cells | | Concentration: | 0.01-10 μM | | Incubation Time: | 15min or 30 min | | Result: | Significantly increased phosphorylation of Smad protein, 50% to 257% higher compared to control after 30 min.
Showed a significant increase in p-Akt expression levels, exceeding the control by 667-1081% after 15 min. |
Cell Cycle Analysis[1] | Cell Line: | C2C12 cells | | Concentration: | 0.01-10 μM | | Incubation Time: | 24 hours | | Result: | Resulted in a significant decrease in the percentage of G0/G1 phase cells and a dramatic increase in S and G2/M phase cells. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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