| CAS NO: | 52906-92-0 |
| 包装: | 1mg |
| 市场价: | 2258元 |
| Cas No. | 52906-92-0 |
| 别名 | 胃动素 (人类，猪) |
| 化学名 | (2S,3Z,6Z,8S,9Z,11S,12Z,14S,15Z,17S,18Z,20S,21Z,23S,24Z,26S,27Z,29S,30Z,32S,33Z,35S,36Z,38S,39Z,41S)-41-((Z)-((1Z,3S,4Z,6S,7Z,9S,10Z,12S,13Z)-1-((S)-1-((S)-2-((Z)-((S)-2-amino-1-hydroxy-3-phenylpropylidene)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-6-benzyl |
| Canonical SMILES | CC[C@]([C@@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@](N)([H])CC2=CC=CC=C2)([H])C(C)C)=O)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@ |
| 分子式 | C120H188N34O35S |
| 分子量 | 2699.07 |
| 溶解度 | 25mg/mL in DMSO & DMF, slightly soluble in ethanol |
| 储存条件 | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line. [Bpa1,Ile13]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC50 = 1.5 ± 0.4 nM)[1]. Motilin binds with high affinity (IC50 0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca2+ release, and increases cytosolic free Ca2+. Motilin induces a biphasic, concentration-dependent contraction (EC50 = 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction[2]. References: |
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