YK11 is a partial agonist ofandrogen receptor, with osteogenic activity.

Androgen receptor^[1]

YK11 is a partial agonist of androgen receptor, and induces myogenic differentiation of C2C12 Cells at 500 nM via Fst mRNA upregulation by AR. YK11 enhances Myf5 and myogenin mRNA expression, but requires high concentrations (YK11, 100 nM or 500 nM)^[1]. YK11 (0.5 μM) increases the cell growth of osteoblastic MC3T3-E1 cells, and enhances ALP activity via AR. YK11 also elevates osteoprotegerin mRNA expression (0.5 μM) and dose-dependently increases osteocalcin mRNA expression (0.1-1.0 μM). In addition, YK11 enhances phosphorylation of Akt protein via rapid non-genomic signaling^[2].

430.53

Solid

C₂₅H₃₄O₆

1370003-76-1

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 64 mg/mL(148.65 mM)

*"≥" means soluble, but saturation unknown.

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