Testosterone undecanoate是睾酮酯，用做男性节育。
| 生物活性 | Testosterone undecanoate is an ester of testosterone; used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive. |
体外研究
(In Vitro) | Cell Viability Assay[1] | Cell Line: | The MCF-7 [ER+, progesterone receptor (PR)+ and AR+] breast cancer cells | | Concentration: | 20 and 200 μg/mL | | Incubation Time: | 0, 24, 48 and 72 hours | | Result: | Following 48 h of treatment, the Testosterone undecanoate and all drug combination groups had significantly fewer viable cells than those of the Anastrozole-treated group.
Following treating for 72 h, the cellular proliferation inhibition rates in all groups were higher than at 0-24 h and the results revealed that the drug combination groups eradicated more cancer cells than the Anastrozole-treated group. |
Western Blot Analysis[1] | Cell Line: | MCF-7 cells | | Concentration: | 0.1 μg/mL Anastrozole + 20 or 200 μg/mL Testosterone undecanoate and 0.01 μg/mL Anastrozole + 20 or 200 μg/mL Testosterone undecanoate | | Incubation Time: | 24 and 48 hours | | Result: | The AR protein expression levels were significantly reduced in the 0.1 μg/mL + 20 μg/mL combined treatment group, compared with those of the 20 μg/mL Testosterone undecanoate-treated group.
The AR expression levels in the 0.1 μg/mL + 200 μg/mL experimental group were significantly lower than those is the 200 μg/mL Testosterone undecanoate-treated group. |
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| 中文名称 | 十一酸睾酮；十一酸睾丸素；十一烷酸睾酮；十一酸睾丸酮 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: DMSO : 6.67 mg/mL(14.60 mM;ultrasonic and warming and heat to 60℃) 配制储备液 | 1 mM | 2.1896 mL | 10.9481 mL | 21.8962 mL | | 5 mM | 0.4379 mL | 2.1896 mL | 4.3792 mL | | 10 mM | 0.2190 mL | 1.0948 mL | 2.1896 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂： ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶 1. 请依序添加每种溶剂： 10% DMSO 40%PEG300 5%Tween-80 45% saline Solubility: ≥ 0.67 mg/mL (1.47 mM); Clear solution
此方案可获得 ≥ 0.67 mg/mL (1.47 mM，饱和度未知) 的澄清溶液。 以 1 mL 工作液为例，取 100 μL 6.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。 2. 请依序添加每种溶剂： 10% DMSO 90%corn oil Solubility: ≥ 0.67 mg/mL (1.47 mM); Clear solution
此方案可获得 ≥ 0.67 mg/mL (1.47 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。 以 1 mL 工作液为例，取 100 μL 6.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。 *以上所有助溶剂都可在本网站选购。
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