(Rac)-ErSO-DFP

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(Rac)-ErSO-DFP

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2768139-73-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

(Rac)-ErSO-DFP 是一种 ErSO-DFP 的衍生物和选择性小分子Erα生物调节剂。(Rac)-ErSO-DFP 通过过度激活ERα+依赖性的预期未折叠蛋白反应来发挥抗雌激素受体 α 阳性乳腺癌 (包括其抗性肿瘤) 的活性 (摘自专利 WO2022087234A1)。

生物活性

(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small moleculeErαbiomodulator. (Rac)-ErSO-DFP againstsERα+breastcancer(including resistant tumors) by hyperactiving theErα-dependent a-UPR (extracted from patent WO2022087234A1)^[1].

IC₅₀& Target

IC50: 35 nM (MCF-7 cells)^[1].

体外研究
(In Vitro)

(Rac)-ErSO-DFP (compound 2) (0.001-1 μM; 24 h) maintains potent anticancer activity with IC₅₀of 35 nM in MCF-7 cells^[1].

Cell Viability Assay^[1]

Cell Line:	MCF-7 cells
Concentration:	0.001-1 μM
Incubation Time:	24 h
Result:	Showed a sustained activity of anticancer with IC₅₀of 35 nM.

体内研究
(In Vivo)

(Rac)-ErSO-DFP (compound 2) (5 mg/kg; i.v.; 3xq.wk.) shows a sustained activity of againsting ERα+ breast cancer at low doses^[1].

Animal Model:	Ovariectomized Nu/J mice (MCF-7 orthotopic tumor model)^[1].
Dosage:	5 mg/kg
Administration:	Intravenous injection; once-a-week for 3 total doses.
Result:	Maintained the ability to regress MCF-7 tumors in a mouse model of ERα+ breast cancer.

分子量

412.35

Formula

C₂₀H₁₇F₅N₂O₂

CAS 号

2768139-73-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.