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C-Type Natriuretic Peptide(CNP)(1-22),human TFA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:1966153-17-2
包装与价格：
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA)，是 CNP 的 1-22 片段，是一种利钠肽受体 B (NPR-B) 激动剂。C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) 抑制由生理激动剂组胺和 5-HT 刺激或直接由 Forskolin 刺激的 cAMP 合成。CNP 是一种有效的、内皮衍生的松弛剂和生长抑制因子。
生物活性

C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is anatriuretic peptide receptor B(NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor[1][2][3].

IC50& Target[1]

NPR-B

 

体外研究
(In Vitro)

C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) (0.01, 0.1, 1, 10, 100, 1000 nM) increases cGMP production in CHO cells expressing human NPR-B in a concentration-dependent manner[1].

体内研究
(In Vivo)

PK parameters of CNP immunoreactivity after a single intravenous administration of C-Type Natriuretic Peptide (CNP) (1-22), human[1]:

Dose
(nM/kg)		AUC0-∞
(pM·min/mL)		MRT0-∞
(min)		T1/2
(min)		CLtot
(mL/min/kg)		Vdss
(mL/kg)
20320±541.02±0.181.42±0.4563.9±11.964.2±5.1
PK parameters of CNP immunoreactivity after a single subcutaneous administration of C-Type Natriuretic Peptide (CNP) (1-22), human[1]:
Dose
(nM/kg)		Cmax
(pM/mL)		Tmax
(min)		AUC0-∞
(pM·min/mL)		MRT0-∞
(min)		T1/2
(min)		BA
(%)
509.02±3.745.0±0.0152±7313.9±3.410.0±5.019±9
Each value represents the mean±SD of 3 rats. MRT=mean residence time, CLtot=total clearance, T1/2=half-life period, BA=bioavailability.
i.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide[3].

分子量

2311.62

性状

Solid

Formula

C95H158F3N27O30S3

CAS 号

1966153-17-2

Sequence Shortening

GLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge: Cys6-Cys22)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 2 mg/mL(0.87 mM;Need ultrasonic)