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3-chloro-5-hydroxybenzoic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
3-chloro-5-hydroxybenzoic Acid图片
CAS NO:53984-36-4
包装与价格：
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
3-Chloro-5-hydroxybenzoic acid 是一种有效的、具有口服活性的，选择性乳酸受体GPR81激动剂，对人 GPR81 的EC50为 16 μM。3-Chloro-5-hydroxybenzoic acid 在肥胖小鼠模型中显示出良好的体内脂肪分解作用。
生物活性

3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptorGPR81agonist, with anEC50of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity[1].

体外研究
(In Vitro)

3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM)[1].

体内研究
(In Vivo)

3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg[1].
Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice[1].

dose (mg/kg)tmax(h)AUCinf(h ng/mL)Cmax(ng/mL)Cmax(μM)t1/2(h)
300.5935611689.5067.21.47
1000.55131255252.80341.91.10

Animal Model:C57Bl6/J mice (DIO mice)[1]
Dosage:30, 100, and 300 mg/kg
Administration:PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks
Result:Significant reductions in nonesterified free fatty acid cholesterol (NEFAc) at all doses tested.
分子量

172.57

性状

Solid

Formula

C7H5ClO3

CAS 号

53984-36-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL(579.47 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM5.7947 mL28.9737 mL57.9475 mL
5 mM1.1589 mL5.7947 mL11.5895 mL
10 mM0.5795 mL2.8974 mL5.7947 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。