LOM612 is a potentFOXOrelocator, with anEC₅₀value of 1.5 μM in U2fox RELOC cells^[1].

EC50: 1.5 μM (FOXO, in U2fox RELOC cells)^[1]

LOM612 potently activates nuclear translocation of FOXO with an EC₅₀value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC₅₀value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC₅₀, 2.76 μM)^[1].

258.30

Solid

C₁₃H₁₀N₂O₂S

2173232-79-4

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

DMSO : 6 mg/mL(23.23 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。