MRGPRX1 agonist 4 (compound 1t) is a potent and orally activeMas-related G protein-coupled receptor X1 (MRGPRX1)positive allosteric modulator with anEC₅₀value of 0.1 μM. MRGPRX1 agonist 4 has good metabolic stability and oral bioavailability. MRGPRX1 agonist 4 can reduce behavioral heat hypersensitivity in a neuropathic pain model humanized MRGPRX1 mice. MRGPRX1 agonist 4 can be used for researching neuropathic pain^[1].

EC₅₀: 0.1 μM (MRGPRX1)^[1]

513.36

C₂₃H₁₇Cl₂F₃N₂O₂S

Room temperature in continental US; may vary elsewhere.

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