CAY10452 (compound 3b) 是一种选择性 cyclooxygenase-2 (COX-2) 抑制剂 (IC50=32 nM)，具有抗炎活性。
| Cas No. | 170569-87-6 |
| 别名 | 塞来昔布杂质3 |
| 化学名 | 4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide |
| Canonical SMILES | FC(F)(F)C1=NN(C2=CC=C(S(=O)(N)=O)C=C2)C(C3=CC=CC=C3)=C1 |
| 分子式 | C16H12F3N3O2S |
| 分子量 | 367.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:8): .1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Inhibitors of cyclooxygenase (COX) are generally grouped according to selectivity for COX-1 versus COX-2. However, many COX inhibitors also show an antitumor, pro-apoptotic activity that is distinct from COX inhibition - celecoxib is an example. CAY10452 is a celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM), but does not induce apoptosis in prostate cancer cell lines even at 100 uM. CAY10452 is thus a clean, selective tool for the inhibition of COX-2. |
m.cnreagent.com