Ethotoin (Peganone) 是一种用于癫痫研究的口服抗惊厥药，Ethotoin 是一种乙内酰脲，类似于苯妥英。
| Cas No. | 86-35-1 |
| 别名 | 乙苯妥英,Peganone |
| 化学名 | 3-ethyl-5-phenyl-2,4-imidazolidinedione |
| Canonical SMILES | O=C(C(C1=CC=CC=C1)N2)N(CC)C2=O |
| 分子式 | C11H12N2O2 |
| 分子量 | 204.2 |
| 溶解度 | DMSO: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at 2-8℃, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ethotoin is a hydantoin anticonvulsant. It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg. It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the duration of the clonic phase at any dose. Ethotoin (20 mg/kg, i.p.) decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60%, respectively, of control after 16 days of treatment. Formulations containing ethotoin have been used in the treatment of tonic-clonic and complex partial seizures. |
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