S07-2010

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S07-2010

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1223194-71-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

S07-2010 是一种有效的泛AKR1C(醛缩酮还原酶家族 1 成员 C) 抑制剂，其对AKR1C3、AKR1C4、AKR1C1和AKR1C2的IC₅₀分别为 0.19、0.36、0.47 和 0.73 μM。S07-2010 可诱导 A549/DDP 细胞凋亡 (apoptosis)。S07-2010 增强了化疗药物对耐药细胞的细胞毒性。S07-2010 对耐药细胞增殖有明显抑制作用。

生物活性	S07-2010 is a potent pan-AKR1C(aldo-keto reductase family 1 member C) inhibitor, withIC₅₀values of 0.19, 0.36, 0.47, and 0.73 μM forAKR1C3,AKR1C4,AKR1C1andAKR1C2, respectively. S07-2010 inducesapoptosisin A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells^[1].
IC₅₀& Target	IC50: 0.19 ± 0.08 μM (AKR1C3), 0.36 ± 0.15 μM (AKR1C4), 0.47 ± 0.16 μM (AKR1C1), 0.73 ± 0.35 μM (AKR1C2)^[1]
体外研究 (In Vitro)	S07-2010 (0-25 μM, 48h) exhibits obvious cytotoxicity on MCF-7/DOX and A549/DDP, with IC₅₀values of 127.5 and 5.51 μM, respectively^[1].
分子量	371.45
Formula	C₁₉H₂₁N₃O₃S
CAS 号	1223194-71-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.