GW 405833 (L768242) 是一种有效的选择性大麻素受体 2 (CB2) 激动剂，EC50 为 50.7 nM。
| Cas No. | 180002-83-9 |
| 别名 | 1-(2,3-二氯苯甲酰基)-5-甲氧基-2-甲基-3-[2-(4-吗啉基)乙基]-1H-吲哚,L768242 |
| 化学名 | (2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]-methanone |
| Canonical SMILES | COC1=CC=C(N(C(C2=C(Cl)C(Cl)=CC=C2)=O)C(C)=C3CCN4CCOCC4)C3=C1 |
| 分子式 | C23H24Cl2N2O3 |
| 分子量 | 447.4 |
| 溶解度 | DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 5 mg/ml,Ethanol: 0.3 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GW 405833 is a partial agonist of the cannabinoid CB2 receptor (EC50 = 0.65 nM). It is selective for CB2, binding with a Ki value of 14 nM compared to that of CB1 with a Ki value of 2.04 uM. GW 405833 demonstrates anti-inflammatory and antihyperalgesic properties in animal models of inflammation and pain. |
m.cnreagent.com