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6-O-Isobutyrylbritannilactone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
6-O-Isobutyrylbritannilactone图片
CAS NO:1259933-02-2
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
6-O-Isobutyrylbritannilactone 是一种天然的黑素生成抑制剂。6-O-Isobutyrylbritannilactone 是一种倍半萜，可从英菊花中分离得到。6-O-Isobutyrylbritannilactone 抑制 IBMX (HY-12318) 诱导 B16F10 细胞产生黑色素。6-O-Isobutyrylbritannilactone 也调控ERK、PI3K/AKT和CREB，在斑马鱼胚胎模型中显示出抗黑色素原活性。
生物活性

6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibitsIBMX(HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulatesERK,PI3K/AKT, andCREB, shows antimelanogenic activity in zebrafish embryos models[1].

体外研究
(In Vitro)

6-O-Isobutyrylbritannilactone (5-100 μM; 48 h) 对 IBMX (100 μM; 24 h)[1]。
6-O-Isobutyrylbritannilactone (5-30 μM; 12 h) 剂量依赖性地抑制 IBMX 刺激 B16F10 细胞的白化相关 mRNA 水平 (100 μM; 48 h)[1]。
6-O-Isobutyrylbritannilactone (20 μM; 1-9 h) 时间依赖性地抑制 ERK、AKT 和 CREB 的磷酸化[1]。

RT-PCR[1]

Cell Line:B16F10 cells
Concentration:5 μM, 10 μM, 20 μM, 30 μM
Incubation Time:12 hours; with 100 μM IBMX for 48 hours
Result:Inhibited whitening-related mRNA levels, and resulted in completely inhibited expressions of melanogenesis-related protein levels at 20 μM.

Western Blot Analysis[1]

Cell Line:20 μM
Concentration:5 μM, 10 μM, 20 μM, 30 μM
Incubation Time:1 h, 3 h, 6 h, and 9 h
Result:Inhibited the phosphorylation of ERK, AKT, and CREB. Demonstrated the melanogenesis suppression induced by IBMX via inaction of multiple signaling pathways.

Cell Cytotoxicity Assay[1]

Cell Line:B16F10 cells
Concentration:5 μM, 10 μM, 20 μM, 50 μM, and 100 μM
Incubation Time:24 hours
Result:Inhibited B16F10 cells viability in a dose-dependent manner.
体内研究
(In Vivo)

6-O-Isobutyrylbritannilactone (10-100 μM; 48 h) 与未处理的对照组相比，显著减少斑马鱼胚胎中的色素沉着[1]。

Animal Model:Zebrafish embryos[1]
Dosage:10 μM, 50 μM, and 100 μM
Administration:Dipped in culture for 48 hours
Result:Reduced pigmentation by approximately 8%, 13%, and 16%.
分子量

336.42

Formula

C19H28O5

CAS 号

1259933-02-2

结构分类
  • Terpenoids
来源
  • Plants
  • Compositae
  • Helianthus tuberosusL.
  • Plants
  • Orchidaceae
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.