SR1555 是一种特异性视黄酸受体相关孤儿受体 γ (RORγ)反向激动剂，IC50为 1 μM。SR1555 不仅能抑制 TH17 细胞的发育和功能，还能增加 T 调节性细胞的出现次数，抑制 IL-17 的表达。SR1555 可用于自身免疫性疾病的研究。
| 生物活性 | SR1555 is a specificretinoic acid receptor-related orphan nuclear receptor γ (RORγ)inverse agonist with anIC50value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression ofIL-17. SR1555 can be used for researching autoimmune diseases[1]. |
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体外研究
(In Vitro) | SR1555 (10 μM; 24 h) inhibitsIl17agene expression by greater than 70%in EL4 cells[1].
SR1555 (10 μM; 24 h) inhibits IL-17 protein expression, inhibits TH17 cell differentiation and function, and does not induce cell death during TH17 cell differentiation[1].
SR1555 (10 μM; 24 h) effectively increases the gene expression ofFoxp3while simultaneously suppressing the gene expression ofRorγt[1].
SR1555 increases the frequency of T regulatory cells as evidenced by the almost 2-fold increase in the expression of Foxp3+ T cells in the splenocyte culture[1].
RT-PCR[1] | Cell Line: | EL4 cells | | Concentration: | 10 μM | | Incubation Time: | 24 h | | Result: | InhibitedIl17agene expression by greater than 70%. |
Cell Differentiation Assay[1] | Cell Line: | Splenocytes (cultured under TH17 polarizing conditions for 3 days) | | Concentration: | 10 μM | | Incubation Time: | 24 h | | Result: | Inhibited IL-17 protein expression, inhibited TH17 cell differentiation and function, and did not induce cell death during TH17 cell differentiation. |
RT-PCR[1] | Cell Line: | Splenocytes (cultured under T regulatory cell polarizing conditions for 3 days) | | Concentration: | 10 μM | | Incubation Time: | 24 h | | Result: | Effectively increased the gene expression ofFoxp3while simultaneously suppressing the gene expression ofRorγt. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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