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Saxagliptin HCl hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Saxagliptin HCl hydrate图片
CAS NO:1073057-20-1
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
Saxagliptin HCl (also known as BMS-477118; brand name: Onglyza) is a potent, orally bioactive,
selective and reversible DPP4 (dipeptidyl peptidase-4) inhibitor with
IC50 of 26 nM. Saxagliptin was approved in 2008 by FDA for the treatment
of type 2 diabetes. Saxagliptin is a competitive DPP4 inhibitor that
slows the inactivation of the incretin hormones, thereby increasing
their bloodstream concentrations and reducing fasting and postprandial
glucose concentrations in a glucose-dependent manner in patients with
type 2 diabetes mellitus. In vitro, saxagliptin inhibits FBS-, insulin-
and IGF1-induced ERK phosphorylation and cell proliferation, in both MSC
and MC3T3E1 preosteoblasts. In the absence of growth factors,
saxagliptin has no effect on ERK activation or cell proliferation.