TPP-1

立即咨询

TPP-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2426685-25-6

包装与价格：

包装	价格(元)
25mg	电议
50mg	电议
100mg	电议

产品介绍

TPP-1 是PD-1/PD-L1相互作用的有效抑制剂。TPP-1 与 PD-L1 特异性高亲和力结合 (K_D=95 nM)。动物模型中，TPP-1 通过再激活 T 细胞功能抑制肿瘤生长。

生物活性

TPP-1 is a potent inhibitor of the PD-1/PD-L1interaction. TPP-1 binds specifically toPD-L1with a high affinity (K_D=95 nM). TPP-1 inhibits human tumor growthin vivovia reactivating T-cell function^[1].

体外研究
(In Vitro)

TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The K_D value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1^[1].
TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation^[1].

体内研究
(In Vivo)

TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors^[1].

Animal Model:	5 to 6-week-old female Balb/c nude mice injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector^[1]
Dosage:	4 mg/kg
Administration:	Subcutaneous injection; 4 mg/kg; every other day eight times; 32days
Result:	Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.

分子量

2488.67

性状

Solid

Formula

C₁₀₇H₁₅₀N₃₄O₃₂S₂

CAS 号

2426685-25-6

Sequence Shortening

SGQYASYHCWCWRDPGRSGGSK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 50 mg/mL(20.09 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.4018 mL	2.0091 mL	4.0182 mL
5 mM	0.0804 mL	0.4018 mL	0.8036 mL
10 mM	0.0402 mL	0.2009 mL	0.4018 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。