PD-1/PD-L1-IN-25

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PD-1/PD-L1-IN-25

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2768759-52-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PD-1/PD-L1-IN-25 (compound D2) 是PD-1/PD-L1互作的抑制剂，IC₅₀值为 16.17 nM。PD-1/PD-L1-IN-25 能够激活 PBMCs 中 T 细胞的抗肿瘤免疫。PD-1/PD-L1-IN-25 可用于癌症的研究。

生物活性

PD-1/PD-L1-IN-25 (compound D2) is an inhibitor ofPD-1/PD-L1interaction with anIC₅₀value of 16.17 nM. PD-1/PD-L1-IN-25 activates the antitumor immunity of T cells efficiently in PBMCs. PD-1/PD-L1-IN-25 can be used for the research ofcancer^[1].

IC₅₀& Target

IC50: 16.17 nM (PD-1/PD-L1)^[1].

体外研究
(In Vitro)

PD-1/PD-L1-IN-25 (0-1 μM; 90 min) inhibits PD-1/PD-L1 interaction with anIC₅₀value of 16.17 nM^[1].
PD-1/PD-L1-IN-25 (0-2 μM; 2 h) activates the antitumor immunity of T cells efficiently in PBMCs^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	MDA-MB 231 cells by human PBMCs
Concentration:	0-2 μM
Incubation Time:	2 hours
Result:	Showed no toxicity towards MDA-MB 231 cells, and activated the antitumor immunity of PBMCs to kill MDA-MB 231 cells efficiently at a concentration of 1.0 μM.

分子量

493.94

Formula

C₂₆H₂₄ClN₃O₅

CAS 号

2768759-52-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.