BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTACPD-1/PD-L1degrader-1 (HY-131183) to degradePD-1/PD-L1^[1]. BMS-1166 is a potentPD-1/PD-L1interaction inhibitor with an IC₅₀of 1.4 nM. BMS-1166 antagonizes the inhibitory effect ofPD-1/PD-L1immune checkpoint on T cell activation^[2].

639.14

Solid

C₃₇H₃₅ClN₂O₆

2447066-00-2

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)