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Myelin Oligodendrocyte Glycoprotein Peptide(35-55),mouse,rat
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:149635-73-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品名称
MOG (35-55)
产品介绍
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) 是中枢神经鞘的一个次要成分。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat 有致脑炎活性，诱导 T 细胞增殖。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat 诱导 Th1 细胞因子反应以及相对高水平的 IgG 抗体出现。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat 引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。
生物活性

Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat has encephalitogenic activity and induces T cell proliferative. Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat induces Th1 cytokine response as well as relatively high levels ofIgGantibodies. Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat produces a relapsing-remittingneurological diseasewith extensive plaque-like demyelination[1][2][3].

体外研究
(In Vitro)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55); 0-50 μg/mL; 72 h; lymph nodes cells) induces T cell proliferative and secretes Th1 cytokines including IFN-γ, TNF-α, IL-10, IL-4 and IL-5. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat increases the level of IgG[1].

体内研究
(In Vivo)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55); 200 μg (0.2 mL); i.p.; once, for 38 d) has encephalitogenic activity in HLA-DR2 (DRB1*1501) mice[1].

Animal Model:HLA-DR2 (DRB1*1501) mice[1]
Dosage:200 μg (0.2 mL)
Administration:Intraperitoneal injection; once, for 38 days
Result:Resulted in paralysis of both hind and forelimbs.
分子量

2581.95

Formula

C118H177N35O29S

CAS 号

149635-73-4

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.