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Goserelin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Goserelin图片
CAS NO:65807-02-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
戈舍瑞林
ICI 118630
产品介绍
Goserelin (ICI 118630) 是一种促性腺激素释放激素 (GnRH/LHRH) 十肽类似物,能作为GnRH激动剂。Goserelin 可用于乳腺癌、上皮性卵巢癌和前列腺癌的研究。
生物活性

Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as aGnRHagonist. Goserelin can be used for the research of breastcancer, epithelial ovariancancerand prostatecancer[1][2].

IC50& Target

GnRH[1]

体外研究
(In Vitro)

Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].

Apoptosis Analysis[1]

Cell Line:SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration:1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM
Incubation Time:48 hours, 72 hours
Result:Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells.

Western Blot Analysis[1]

Cell Line:SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration:1 nM, 10 nM, 100 nM, 1μM , 10 μM, 100 μM, 1 mM
Incubation Time:48 hours, 72 hours
Result:The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM.

RT-PCR[1]

Cell Line:SKOV3-ip cells
Concentration:100 μM
Incubation Time:24 hours, 48 hours, 72 hours
Result:Expression of human apoptosis-related genes regulated
体内研究
(In Vivo)

Goserelin (100 μg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].

Animal Model:Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model[1]
Dosage:100 μg/mice
Administration:Subcutaneous injection, daily, for 19 days
Result:Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors
Clinical Trial
分子量

1269.41

Formula

C59H84N18O14

CAS 号

65807-02-5

中文名称

戈舍瑞林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.