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Histrelin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Histrelin图片
CAS NO:76712-82-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
组氨瑞林
产品介绍
Histrelin,一种 GnRH 类似物,是一种GnRH受体激动剂。Histrelin 可增加血清中促黄体激素(LH)、促卵泡激素 (FSH) 和睾酮水平。Histrelin 可用于前列腺癌、子宫内膜异位症的研究。
生物活性

Histrelin, a GnRH analogue, is aGnRH Receptoragonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostatecancer, endometriosis[1][2][5].

IC50& Target

GnRH Receptor[1]

体外研究
(In Vitro)

Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants[4].
Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system[5].

体内研究
(In Vivo)

Histrelin (0.1 mg/kg, subcutaneous injection) rescues the circulating LH concentrations inCsfmop/Csfmopmice[2].
Histrelin (10,30, or 100 μg /day, subcutaneous injection) reduces the number of endometrial glands and atrophied the stroma in rabbits[3].

Animal Model:Csfmop/Csfmopmice[2]
Dosage:0.001, 0.05, and 0.1 mg/kg
Administration:Subcutaneous injection
Result:Increased serum FSH concentrations by 4-fold.
Animal Model:Rabbits[3]
Dosage:10, 30, or 100 μg /day
Administration:Subcutaneous injection for 4 weeks
Result:Caused a regression of the endometrial glands and a thinning of the stroma.
Clinical Trial
分子量

1323.50

Formula

C66H86N18O12

CAS 号

76712-82-8

中文名称

组氨瑞林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.