| CAS NO: | 42461-84-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Molecular Weight (MW) | 491.46 |
|---|---|
| Formula | C14H11F3N2O2.C7H17NO5 |
| CAS No. | 42461-84-7 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 98 mg/mL (199.4 mM) |
| Water: 98 mg/mL (199.4 mM) | |
| Ethanol: 8 mg/mL (16.3 mM) | |
| Other info | Chemical Name: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinate InChi Key: MGCCHNLNRBULBU-WZTVWXICSA-N InChi Code: InChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1 SMILES Code: O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2C)O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC |
| Synonyms | Banamine; Flumeglumine; Flunixin meglumine; Flunixin-S |
| In Vitro | In vitro activity: An in vitro whole blood model in feedlot calves was adopted to detect the activity of the anti-inflammatory agents Flunixin-meglumine (FLU), RS (±) Carprofen (CPF) and S (+) CPF. The drugs all exhibited inhibitory activity on COXs, with an order of FLU> S (+) CPF> RS (±) CPF in their potency. This finding indicated that FLU was a nonselective suppressorr of bovine COXs, whereas RS (±) CPF and S (+) CPF selectively inhibited COX-2 isoenzyme. |
|---|---|
| In Vivo | Findings from mice, rats and monkeys suggested Flunixin meglumine as a potent non-narcotic analgesic agent after parenteral administration. After being subcutaneous administered, this agent showed higher efficacy than pentazocine, meperidine and codeine in the rat yeast paw test. Intramuscular administration and subcutaneous administration of Flunixin meglumine had similar effects. Moreover, orally administered Flunixin meglumine also exerted analgesic and anti-inflammatory activities. Based on mice abdominal constriction test, flunixin meglumine had comparable efficacy to pentazocine and was more potent than meperidine and codeine. In primates, 10 mg/kg flunixin meglumine showed an equal efficacy to that of 0.3 mg/kg morphine. |
| Animal model | Mice, rats and monkeys |
| Formulation & Dosage | 10 mg/kg |
| References | J Vet Pharmacol Ther. 2014 Feb;37(1):43-52; J Pharmacol Exp Ther. 1977 Mar;200(3):501-7. |
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