FLT3-IN-17

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FLT3-IN-17

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2758999-62-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

FLT3-IN-17 抑制CYPs和FLT3突变体的活性 (IC₅₀s:<0.5 nM for D835Y)。FLT3-IN-17 也是一种FAK抑制剂，IC₅₀值为 12 nM。FLT3-IN-17 可用于癌症研究。

生物活性

FLT3-IN-17 inhibitsCYPsandFLT3mutants activity (IC₅₀s:<0.5 nM for D835Y). FLT3-IN-17 is also aFAKinhibitor, with anIC₅₀value of 12 nM.FLT3ligand-2 can be used in the research of cancers^[1].

IC₅₀& Target

IC50: 12 nM (FAK),<0.5 nM (D835Y)^[2].

体外研究
(In Vitro)

FLT3-IN-17 (compound 25, 72 h) inhibits cell growth in HCT-116, MDA-MB-231, A375 cells^[1].
FLT3-IN-17 (10 μM) inhibits cytochrome P450s (CYPs) with inhibition rates >55%^[1].
FLT3-IN-17 inhibits FLT3 mutants activity (IC₅₀s:<0.5 nM for D835Y, 1.6-183 nM for Ba/F3)^[1].

Cell Proliferation Assay^[1]

Cell Line:	HCT-116, MDA-MB-231, A375 cells
Concentration:	0-1 μM approximately
Incubation Time:	72 h
Result:	Inhibited cell growth with IC₅₀values of 0.25, 0.46, 0.49 μM respectively.

分子量

480.61

Formula

C₂₃H₂₄N₆O₂S₂

CAS 号

2758999-62-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.