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Atrial natriuretic factor(1-28)(rat)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Atrial natriuretic factor(1-28)(rat)图片
CAS NO:88898-17-3
包装:1mg
市场价:2510元

产品介绍
Atrial natriuretic factor (1-28) (rat) 是大鼠体内 ANP 的主要循环形式，以浓度依赖性方式有效抑制血管紧张素 II (Ang II) 刺激的 endothelin-1 分泌。
Cas No.88898-17-3
别名心钠肽,Atrial natriuretic factor (1-28) (rat)
化学名(1Z,3S,4Z,6S,7Z,9S,10Z,12S,13Z,15S)-1-((4R,5Z,8Z,10S,11Z,14E,16S,17Z,19S,20Z,22S,23Z,26Z,28S,29Z,31S,32Z,34S,35Z,37S,38Z,40S,41Z,44Z,47Z,49S,50E,52R)-52-((Z)-((2S,3Z,5S,6Z,8S,9Z,11S,12Z,14S,15Z,17S)-17-amino-8,11-bis(3-guanidinopropyl)-1,4,7,10,13,16,18-h
Canonical SMILESCC[C@]([C@@]1([H])/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N\C/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=O)([H])CC2=CC=C(O)C=C2)([H])CCCNC(N)=N)([H])CC3=CC=CC=C3)([H])CO)
分子式C128H205N45O39S2
分子量3062.43
溶解度Soluble in Water
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Atrial Natriuretic Peptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

Rat ANP (1-28) and rat BNP-45, which are the respective major circulating forms of ANP and BNP in rats, potently inhibited Ang II-stimulated endothelin-1 secretion in a concentration-dependent manner. Rat ANP (5-25) is less effective that Rat ANP(1-28) with respect to inhibiting immunoreactive (ir)-endothelin-1 secretion and increasing cellular cyclic GMP. Rat ANP (1-28) inhibits the secretion of ir-endothelin-1 in a concentration-dependent manner between 0.01 and 1 μM[1].

References:
[1]. Kohno M, et al. Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells. Kidney Int. 1992 Oct;42(4):860-6.