| CAS NO: | 21256-18-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 293.32 |
|---|---|
| Formula | C18H15NO3 |
| CAS No. | 21256-18-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 59 mg/mL (201.1 mM) |
| Water: <1 mg/mL | |
| Ethanol: 27 mg/mL (92.0 mM) | |
| Other info | Chemical Name: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid InChi Key: GSDSWSVVBLHKDQ-UHFFFAOYSA-N InChi Code: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25) SMILES: CC1COC2=C3N1C=C(C(O)=O)C(C3=CC(F)=C2N4CCN(C)CC4)=O |
| Synonyms | WY21743; Oxaprozin, Oxaprozinum, DL-8280, WY-21743; WY 21743; DR-3355, Hoe-280, ORF-28489, Ru-43280, Tarivid |
| In Vitro | In vitro activity: Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Curr Med Res Opin. 2004 Aug;20(8):1275-7. |
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