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Urocortin(human)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Urocortin(human)图片
CAS NO:176591-49-4
包装:1mg
市场价:2430元

产品介绍
Urocortin (human) 是一种 40-aa 神经肽，作为\u200b\u200b内源性 CRF2 受体的选择性激动剂，对 hCRF1、rCRF2α 和 mCRF2β 的 Kis 分别为 0.4、0.3 和 0.5 nM。
Cas No.176591-49-4
别名人尿皮质素,Urocortin (human); Human urocortin; Human urocortin 1; Human urocortin I
分子式C204H337N63O64
分子量4696.29
溶解度Soluble in Water
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively.

Urocortin, human is a selective agonist of CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF2α and mouse CRF2β receptors in cell assay, respectively[1].

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2].

References:
[1]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.
[2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.