A2A receptor antagonist 3 (Example 92) is anadenosine A2a receptorantagonist with aK_iof 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with K_is of 37, 107 and 1467 nM, respectively^[1].

A2A receptor antagonist 3 (Example 92) (24 h) inhibits CD3/CD28 stimulated IL-2 release with an IC₅₀of 0.004 μM^[1].
A2A receptor antagonist 3 (20 min) inhibits pCREB in CD8+T cells in human whole blood with an IC₅₀of 0.02 μM^[1].

454.52

C₂₆H₂₆N₆O₂

2738606-83-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.