VCP171

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VCP171

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1018830-99-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

VCP171 是一种有效的腺苷 A1 受体 (A1R)正向变构调节剂。VCP171 能有效降低神经性疼痛模型 Lamina II 的兴奋性突触电流。VCP171 可用于神经性疼痛的研究。

生物活性

VCP171 is a potentadenosine A1 receptor (A1R)positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain^[1].

IC₅₀& Target^[1]

A1R

体内研究
(In Vivo)

VCP171 (10 μM) reduces AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in lamina I cells in sham and nerve-injured animals; increases paired pulse ration in cells from sham control animals; is significantly more effective in Lamina II neurons from nerve-injured animals than sham controls^[1].

Animal Model:	Neurons from male Sprague-Dawley rats (5-6 weeks; performed a partial nerve ligation (PNL) of the left sciatic nerve to create neuropathic pain model)^[1]
Dosage:	10 μM
Administration:	0-30 min
Result:	Reduced AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in Lamina I cells in sham (13±2%, n=7 cells) and nerve-injured animals (24±4%, n=8 cells) compared with predrug controls; increased paired pulse ration in cells from sham control animals; was significantly more effective in Lamina II neurons from nerve-injured animals than sham controls.

分子量

347.35

Formula

C₁₈H₁₂F₃NOS

CAS 号

1018830-99-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.