BP 897 hydrochloride is a potent and partialdopamine D3 receptoragonist and a weakD2receptor antagonist. BP 897 hydrochloride displays a high affinity at thedopamine D3 receptor(K_i=0.92 nM) and a 70 times lower affinity at the D2 receptor (K_i=61 nM). BP 897 exhibits selective inhibition of cocaine-seeking behavior^[1].

Ki: 0.92 nM (D3 receptor), 61 nM (D2 receptor), 0.3 μM (D4 receptor), 3 μM (D1 receptor)^[1].

BP 897 hydrochloride also displays low affinities at D1 and D4 receptors (K_i=3 and 0.3 μM, respectively), as well as at α1 and α2 adrenergic receptors (K_i=60 and 83 nM, respectively), 5HT1A and 5HT7 receptors (K_i=84 and 345 nM, respectively), and negligible affinities (K_i>1 μM) atmuscarinic, histamine and opiate receptors^[1].
In NG 108-15 cells expressing the human D3 receptor, BP 897 hydrochloride inhibits forskolin-induced cyclic AMP accumulation with an EC₅₀of 1 nM. BP 897 hydrochloride activates mitogenesis and this response is antagonized by the preferential D3 receptor antagonist Nafadotride (1 μM). BP 897 hydrochloride also partially antagonized the response induced by quinpirole (10 nM)^[1].

BP 897 hydrochloride binds to D2-receptor in mouse striatum with an ED₅₀of 15 mg/kg, and the D3-receptor occupancy is blow 0.5 mg/kg. BP 897 (0.05, 0.5, 1 mg/kg; i.p.; 30 min before the session) hydrochloride reduces cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 hydrochloride produced its responses on rotations and c-fos expression^[1].

454.00

Solid

C₂₆H₃₂ClN₃O₂

314776-92-6

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

DMSO : 125 mg/mL(275.33 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。