Dopamine

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Dopamine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

51-61-6

包装与价格：

包装	价格(元)
100mg	电议
500mg	电议

产品名称

ASL279 free base

产品介绍

Dopamine 是在脑黑质，脑腹侧被盖区和下丘脑中产生的一种儿茶酚胺类神经递质，在大脑和身体中起着重要作用。Dopamine 通过 D2 多巴胺受体 (D2 dopamine receptor) 来诱导 VEGFR2 的内吞作用，这对于促进血管生成是至关重要的。

生物活性

Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body^[1]. Dopamine acts throughD2dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis^[1].

IC₅₀& Target

Human Endogenous Metabolite

Microbial Metabolite

D2 Dopamine Receptor

体外研究
(In Vitro)

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 μM; 24hours)^[2].

Cell Proliferation Assay^[2]

Cell Line:	HUVECs
Concentration:	1 μM
Incubation Time:	24 hours
Result:	Inhibited VPF/VEGF-induced HUVEC proliferation specifically through its D2 receptor.

体内研究
(In Vivo)

Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF^[2].

Animal Model:	Syngeneic C3Heb/FeJ mice with MOT ascites tumors^[2]
Dosage:	50 mg/kg
Administration:	I.p. injection; 7 days
Result:	Corresponding to ~5% of the median lethal dose (LD₅₀) in mice) beginning at 24 hours after tumor-cell injection and continuing daily for 7 days.

分子量

153.18

Formula

C₈H₁₁NO₂

CAS 号

51-61-6

中文名称

多巴胺

结构分类

Phenols
Polyphenols

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.