CAS NO: | 402616-23-3 |
包装 | 价格(元) |
500μg | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 402616-23-3 |
化学名 | (2R)-amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol |
Canonical SMILES | CCCCCCCCc1ccc(cc1)CC[C@@](N)(CO)COP(=O)(O)O |
分子式 | C19H34NO5P |
分子量 | 387.5 |
溶解度 | 0.5mg/mL in chloroform |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.[1] FTY720 is phosphorylated by sphingosine kinases in vivo, and then acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors.[2] FTY720 (R)-phosphate is one of the stereoisomers of FTY720-phosphate, but it is apparently not formed in vivo.[3] FTY720 (S)-phosphate exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, whereas the R isomer binds with 5 to130-fold lower affinity.[4] Reference: |