| CAS NO: | 223460-79-5 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 生物活性 | GLP-2(1-33) (human) is an enteroendocrine hormone which can bind to theGLP-2 receptorand stimulate the growth of intestinal epithelium. | ||||||||||||||||
| IC50& Target | GLP-2 receptor[1] | ||||||||||||||||
| 体外研究 (In Vitro) | GLP-2-treated group demonstrates a 518±22% increase (P<0.05) in mucosal IGFBP-4 mRNA levels as compare with vehicle-treated controls. Because the mucosal expression of IGFBP-4 transcripts is found to be very low relative to that of the whole intestine, FRIC cultures are used as anin vitromodel of the entire intestine. FRIC cultures have previously been established to express a functional GLP-2 receptor (GLP-2R) that displays a cAMP response, as well as enhances IGF-1 mRNA expression and IGF-1 secretion in response to GLP-2 treatment. When incubates with GLP-2 (10–8M) for 2 hours, IGFBP-4 mRNA expression in the FRIC cultures is also found to be increased, by 40.8±15.2% (P<0.05), compare with vehicle-treated cells[1]. | ||||||||||||||||
| 体内研究 (In Vivo) | GLP-2 quickly increases apoB48 mass in the TRL fraction of plasma, which is indicative of chylomicron number, and this is blocked by L-NAME. GLP-2 treatment alone increases postprandial TRL-lipids (slope 3.65±0.73×10–3g/L/min vs 1.63±0.28×10–3g/L/min, GLP-2 vs control), and this effect is completely mitigated by L-NAME pretreatment (slope 3.67±0.15×10–4g/L/min). The GLP-2-induced rise in TRL-apoB48 occurres within 30 minutes and precedes the rise in TRL-TG. GLP-2 acutely increases plasma tritium levels (slope, 1.66±0.25×102dpm/mL/min vs 1.11±0.17×102dpm/mL/min, GLP-2 vs control)[2]. | ||||||||||||||||
| 分子量 | 3766.19 | ||||||||||||||||
| 性状 | Solid | ||||||||||||||||
| Formula | C165H254N44O55S | ||||||||||||||||
| CAS 号 | 223460-79-5 | ||||||||||||||||
| Sequence | His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp | ||||||||||||||||
| Sequence Shortening | HADGSFSDEMNTILDNLAARDFINWLIQTKITD | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 储存方式 | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
| 溶解性数据 | In Vitro: H2O : 25 mg/mL(6.64 mM;ultrasonic and adjust pH to 9 with NH4OH) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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