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(25S)-┏-Dafachronic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(25S)-┏-Dafachronic Acid图片
CAS NO:949004-12-0
包装:100μg
市场价:4052元

产品介绍
Cas No.949004-12-0
Canonical SMILESO=C1CC[C@@]2(C)C(CC=C3C2CC[C@@]4(C)C3CC[C@@H]4[C@@H](CCC[C@H](C)C(O)=O)C)C1
分子式C27H42O3
分子量414.6
溶解度DMF: 5 mg/ml,DMSO: 2.5 mg/ml,Ethanol: 12.5 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-δ7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM. At 50 nM, (25S)-δ7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.