CAS NO: | 949004-12-0 |
包装: | 100μg |
市场价: | 4052元 |
Cas No. | 949004-12-0 |
Canonical SMILES | O=C1CC[C@@]2(C)C(CC=C3C2CC[C@@]4(C)C3CC[C@@H]4[C@@H](CCC[C@H](C)C(O)=O)C)C1 |
分子式 | C27H42O3 |
分子量 | 414.6 |
溶解度 | DMF: 5 mg/ml,DMSO: 2.5 mg/ml,Ethanol: 12.5 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-δ7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM. At 50 nM, (25S)-δ7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection. |