| CAS NO: | 210580-75-9 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 210580-75-9 |
| 别名 | AL 34497 |
| 化学名 | 1-[(2S)-2-aminopropyl]-1H-indazol-6-ol |
| Canonical SMILES | OC1=CC=C(C=NN2C[C@H](N)C)C2=C1 |
| 分子式 | C10H13N3O |
| 分子量 | 191.2 |
| 溶解度 | ≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 0.8-1.5 nM for rat and human 5-HT2 receptor AL 34662 is a potent 5-HT2 receptor agonist. SEROTONIN (5-hydroxytryptamine; 5-HT) is a major neurotransmitter in the central nervous system (CNS) of mammals and has welldocumented physiological functions in numerous cells, tissues, and organs. In vitro: AL-34662 exhibited a high affinity for the rat and human 5-HT2 receptor and for cloned human 5-HT2A-C receptors. AL-34662 stimulated phosphoinositide turnover in human ciliary muscle and in human trabecular meshwork cells. AL-34662 also mobilized intracellular Ca2+ in h-CM and h-TM cells, being a full agonist like 5-HT itself. AL-34662's effects in the h-CM cells were potently antagonized by 5-HT2A-antagonist M-100907, but weakly by 5-HT2B-antagonist, 5-HT2B/C- antagonist and 5-HT2C antagonist. Moreover, it was found that the (R)-enantiomer (AL-34707) and the racemate (AL-34497) were less potent and/or efficacious than AL-34662 in all of these assays [1]. In vivo: AL-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes. It efficaciously lowered intraocular pressure in the conscious ocular hypertensive monkey eyes [1]. Clinical trial: So far, no clinical study has been conducted. Reference: |
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