(Rac)-BI 703704

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(Rac)-BI 703704

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1423067-48-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

(Rac)-BI 703704 是有效的可溶性鸟苷酸环化酶(sGC)激活剂。(Rac)-BI 703704 减少 ZSF1 大鼠的肾脏损害进展，sGC 激活可作为糖尿病性肾病有效疗法的潜力.

生物活性

(Rac)-BI 703704 is a potentsoluble guanylyl cyclase (sGC)activator. (Rac)-BI 703704 reduces progression of renal damage in the ZSF1 rat, and highlight the potential of sGC activation as an effective therapy for diabetic nephropathy^[1].

体内研究
(In Vivo)

(Rac)-BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) inhibits the progression of diabetic nephropathy in the ZSF1 rat^[1].

Animal Model:	12-13 weeks male ZSF1 obese rats^[1]
Dosage:	0.3, 1, 3, or 10 mg/kg
Administration:	Food intake; daily for 15 weeks
Result:	Dose-dependent increased in renal cGMP levels; Dosedependent decreased in urinary protein excretion (UPE); Accompanied by a significant reduction in the incidence of glomerulosclerosis and interstitial lesions.

分子量

559.72

Formula

C₃₂H₃₇N₃O₄S

CAS 号

1423067-48-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.