Montelukast-d6 sodium (MK0476-d6) is the deuterium labeled Montelukast (sodium). Montelukast sodium is a potent, selective and orally active antagonist ofcysteinylleukotriene receptor1 (Cysltr1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

614.20

Solid

C₃₅H₂₉D₆ClNNaO₃S

2673270-26-1

孟鲁司特钠 d6 (钠盐)

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)