Tipelukast (KCA 757) is a sulfidopeptideleukotriene receptorantagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma.

Tipelukast inhibits the binding of [³H] LTD4 to the LTD4 receptors on pul-monary cell membrane of guinea-pigs (IC₅₀= 2.3 μmol)^[2].

Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, Tipelukast significantly alters the UNDW-induced bronchoconstriction^[1]. Tipelukast (1 and 5 mg/kg) administered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs^[2].

530.67

Solid

C₂₉H₃₈O₇S

125961-82-2

Room temperature in continental US; may vary elsewhere.

Ethanol : 1 mg/mL(1.88 mM;Need ultrasonic and warming)

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