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N-Isopropylnoratropine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-Isopropylnoratropine图片
CAS NO:22235-81-0
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
used in the synthesis of ipratropium, a muscarinic antagonist
Cas No.22235-81-0
别名异丙托品杂质E,NINA
化学名(3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester α-(hydroxymethyl)-benzeneacetic acid
Canonical SMILESO=C(C(CO)C1=CC=CC=C1)O[C@H]2C[C@H]3CC[C@H](N3C(C)C)C2
分子式C19H27NO3
分子量317.4
溶解度≤16mg/ml in ethanol;10mg/ml in DMSO;2mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Isopropylnoratropine is a noratropine derivative and an intermediate in the production of ipratropium, an atropine-like bronchodilator drug via an anticholinergic pathway. N-Isopropylnoratropine is used to examine the stability of ipratropium [1].

Muscarinic acetylcholine receptors are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certain neurons and other cells.

N-Isopropylnoratropine is an intermediate in the production of ipratropium and used to examine the stability of ipratropium. Ipratropium exhibits broncholytic action by reducing the influence of cholinergic on the bronchial musculature. Ipratropium blocks muscarinic acetylcholine receptors and therefore promotes the degradation of cGMP. Ipratropium bromide (IB) is an anticholinergic bronchodilatory agent to treat chronic obstructive pulmonary disease. In anesthetized dogs, Ipratropium with 0.01 and 0.1 mg/ml constricted the airways to 22 +/- 2% and 20 +/- 3% of control, respectively, whereas larger concentrations caused bronchodilation [2]. In moderate asthmatic patients, Ipratropium bromide (IB) induced a significant shift of dose-response curve to inhalation of substance P (SP), suggesting that bronchoconstriction induced by SP could be attributed to a weak cholinergic activation [3].

References:
[1].  Kasawar GB, Farooqui M. Development and validation of a stability indicating RP-HPLC method for the simultaneous determination of related substances of albuterol sulfate and ipratropium bromide in nasal solution. J Pharm Biomed Anal. 2010 May 1;52(1):19-29.
[2].  Groeben H, Brown RH. Ipratropium decreases airway size in dogs by preferential M2 muscarinic receptor blockade in vivo. Anesthesiology. 1996 Oct;85(4):867-73.
[3].  Crimi N, Palermo F, Oliveri R, et al. Influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance P. Ann Allergy. 1990 Aug;65(2):115-20.