A6770 is an orally active, potentsphingosine 1-phosphate (S1P) lyase (S1PL)inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [³H]dhS1P increase^[1][2].

A6770 causes concentration-dependent increases in [³H] dhS1P with the EC₅₀ranging from 30 to 200 μM under the normal condition^[1].
A6770 leads to S1PL inhibition rather than SPHK activation or SPP inhibition^[2].

A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats^[2]

140.14

C₆H₈N₂O₂

1331754-16-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.