FTY720(S)-Phosphate

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FTY720(S)-Phosphate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

402616-26-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

(S)-FTY720P
(S)-FTY720 phosphate

产品介绍

FTY720 (S)-Phosphate 是一种 S1P 受体 1 (S1PR1) 激动剂，可以用于急性肺损伤等急性炎症的研究。

生物活性

FTY720 (S)-Phosphate is an agonist ofS1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

IC₅₀& Target

S1PR1^[1]

体外研究
(In Vitro)

FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1^[1].

体内研究
(In Vivo)

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice^[1].

分子量

387.45

性状

Solid

Formula

C₁₉H₃₄NO₅P

CAS 号

402616-26-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder

-20°C

3 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

In Vitro:

DMSO : 1 mg/mL(2.58 mM;ultrasonic and warming and heat to 80℃)

H₂O :< 0.1 mg/mL(insoluble)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.5810 mL	12.9049 mL	25.8098 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

In Vivo:

1.
FTY720 (S)-Phosphate is dissolved in sterile water^[2].