TC LPA5 4

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TC LPA5 4

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1393814-38-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

TC LPA5 4 是一种特异性非脂质LPA₅(GPR92)拮抗剂。TC LPA5 4 抑制 LPA 诱导的离体人血小板 (LPA5-RH7777细胞系) 聚集，IC₅₀为 800 nM。TC LPA5 4 对 LPA₅的选择性超过 80 个其他筛选药物靶点。TC LPA5 4 抑制甲状腺癌细胞的增殖和迁移。

生物活性

TC LPA5 4 is aLPA₅(GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA₅-RH7777 cell line) with an IC₅₀of 800 nM. TC LPA5 4 displays selectivity for LPA₅over 80 other screened drug targets^[1]. TC LPA5 4 inhibits cell proliferation and migration of thyroidcancercells^[2].

体外研究
(In Vitro)

TC LPA5 4 inhibits the proliferation on thyroid cancer cells CGTH-W3, TPC-1, B-CAPAP, and BHT101 significantly with IC₅₀at 103.0 μM, 84.9 μM, 55.9μM, and 57.17 μM. TC LPA5 4 (5 μM; 24 hours) significantly inhibits LPA-stimulated migration of CGTH-W3 and TPC-1 cells, with an inhibitory rate of ~ 30%. B-CPAP and BHT101 cells expressed higher LPAR5 mRNA. TC LPA5 4 inhibits these two cell lines’ proliferations with IC₅₀at 55.9μM and 57.17 μM. CGTH-W3 and TPC-1 cells expressed lower LPAR5 mRNA. TC LPA5 4 displays differential antitumor activity with IC₅₀at 103.0 μM and 84.9 μM^[2].

体内研究
(In Vivo)

TC LPA5 4 (10 mg/kg; intraperitoneal injection; 5 days/week for 2 weeks) could delay CGTH-W3 xenograft growth in nude mice^[2].

Animal Model:	BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts)^[2]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; 5 days/week for 2 weeks
Result:	Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.

分子量

410.89

性状

Solid

Formula

C₂₃H₂₃ClN₂O₃

CAS 号

1393814-38-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL(152.11 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.4337 mL	12.1687 mL	24.3374 mL
5 mM	0.4867 mL	2.4337 mL	4.8675 mL
10 mM	0.2434 mL	1.2169 mL	2.4337 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。