Biperiden Hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1235-82-1

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

盐酸比哌立登
KL 373 hydrochloride

产品介绍

Biperiden (KL 373) hydrochloride 是一种非选择性毒蕈碱受体 (muscarinic receptor) 拮抗剂，可以与M1毒蕈碱受体竞争性结合，从而抑制乙酰胆碱 (acetylcholine) 并增强中枢神经系统中多巴胺信号传导。 Biperiden hydrochloride 可用于帕金森病以及其他相关精神疾病的研究。

生物活性

Biperiden (KL 373) hydrochloride is a non-selectivemuscarinic receptorantagonist that competitively binds toM1muscarinic receptors, thereby inhibitingacetylcholineand enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders^[1]^[2].

体外研究
(In Vitro)

Biperiden hydrochloride (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	Panc-1, Panc-2 and BxPC3 human pancreatic ductal adenocarcinoma cells
Concentration:	29.6 μg/mL
Incubation Time:	72 hours
Result:	Inhibited cell proliferation at 72 hours significantly by reducing nuclear c-Rel translocation.

体内研究
(In Vivo)

Biperiden hydrochloride (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells^[1].
Biperiden hydrochloride (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability^[2].

Animal Model:	Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; everyday; 3 weeks
Result:	Tumor size reduced by 83%.

Animal Model:	Male Wistar rats (200-250 g)^[2]
Dosage:	8 mg/kg
Administration:	Intraperitoneal injection; every 8 hours; 10 days
Result:	Reduced late seizures by about three times with no affecting emotional memory damage.

Clinical Trial

分子量

347.92

性状

Solid

Formula

C₂₁H₃₀ClNO

CAS 号

1235-82-1

中文名称

盐酸比哌立登；双环哌丙醇盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 20 mg/mL(57.48 mM;Need ultrasonic)

H₂O : 5 mg/mL(14.37 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.8742 mL	14.3711 mL	28.7422 mL
5 mM	0.5748 mL	2.8742 mL	5.7484 mL
10 mM	0.2874 mL	1.4371 mL	2.8742 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。