Blarcamesine

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Blarcamesine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

195615-83-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Blarcamesine 是一种Sigma-1 受体激动剂和毒蕈碱受体 (muscarinic receptor) 调节剂，具有抗惊厥、抗失忆、神经保护和抗抑郁的特性。Blarcamesine 能改善 Rett 综合征小鼠模型的神经功能损害。

生物活性

Blarcamesine is an orally bioavailableSigma-1 receptoragonist andmuscarinic receptormodulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome^[1].

IC₅₀& Target

Sigma-1 receptor, muscarinic receptor^[1]

体内研究
(In Vivo)

Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration^[1].
Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice^[1].
Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response^[1].
Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice^[1].

Animal Model:	Female Mecp2^tm1.1Bird/J HET (C57 background) mice^[1]
Dosage:	10 mg/kg, 30 mg/kg
Administration:	Oral administration, daily, for 6.5 weeks
Result:	Reverse the deficits observed in the HET animals.

Clinical Trial

分子量

281.39

Formula

C₁₉H₂₃NO

CAS 号

195615-83-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.