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BTM-1086
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BTM-1086图片
CAS NO:72293-17-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
BTM-1086是一种有效的抗溃疡和胃分泌抑制剂。
生物活性

BTM-1086 is a potent anti-ulcer and gastric secretory inhibiting agent.

IC50& Target

Muscarinic receptor[1]

体外研究
(In Vitro)

Functional and binding experiments shows that the (-) enantiomer (BTM-1086) has a high affinity (pKi=8.31-9.15) for the three muscarinic receptor subtypes in guinea-pig cortex (M1), heart (M2) and salivary glands (M3)[1].

体内研究
(In Vivo)

BTM-1086 prevents the development of ulcer at a dose of 0.1 to 1 mg/kg, p.o., but only weakly inhibits the histamine induced gastric ulcer. The inhibitory activities of BTM-1086 are significantly higher than those of atropine sulfate. In the healing experiment with the acetic acid-induced stomach ulcer, BTM-1086 (1 mg/kg/day , p.o., x14) shows a significant healing effect, which is higher than that of propantheline bromide . BTM-1086 at a dose of 0.2 mg/kg , i.d., remarkably inhibits the gastric secretion 6 hr after pylorus ligation. The aspirin-induced reductions of the total acid and K+as well as the increments of the volume and Na+in the gastric secretion are prevented dose-dependently by pretreatment with BTM-1086. The LD50value by oral, s.c., and i.v. administration with this compound is 880, 630 and 113 mg/kg, respectively, for male rats and 830, 650 and 119 mg/kg, respectively, for female rats[2].

分子量

367.51

Formula

C21H25N3OS

CAS 号

72293-17-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.