PG-931

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PG-931

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

667430-81-1

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议

产品介绍

PG-931 是 SHU 9119 (HY-P0227) 的类似物。PG-931 是一种强效的黑素皮质素 4 (MC4) 受体 (IC₅₀=0.58 nM) 激动剂，比 hMC3R (IC₅₀=55 nM) 或 hMC5R (IC₅₀=2.4 nM) 更具选择性。PG-931 在动物实验模型中，可逆转出血休克，防止体内多器官损伤。

生物活性

PG-931, an analog of SHU 9119 (HY-P0227), is a potentmelanocortin 4 (MC4) receptor(IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo^[2].

IC₅₀& Target

IC50: 0.58 nM (melanocortin 4 receptor)
IC50: 2.4 nM (melanocortin 5 receptor)
IC50: 55 nM (melanocortin 3 receptor)^[1]

体内研究
(In Vivo)

PG-931 (intravenous injection; 13-10⁸nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock^[2].

Animal Model:	Wistar rats^[2]
Dosage:	13-10⁸nmol/kg
Administration:	Intravenous injection; single dose
Result:	Exhibitd an anti-shock effect occurred at nanomolar doses.

分子量

1180.40

性状

Solid

Formula

C₅₉H₈₅N₁₅O₁₁

CAS 号

667430-81-1

Sequence Shortening

Ac-{Nle}-DP-{D-Phe}-RWKPV-NH2 (Lactam bridge:Asp2-Lys7)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据

In Vitro:

H₂O : 100 mg/mL(84.72 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.8472 mL	4.2359 mL	8.4717 mL
5 mM	0.1694 mL	0.8472 mL	1.6943 mL
10 mM	0.0847 mL	0.4236 mL	0.8472 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。