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S-22153
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
S-22153图片
CAS NO:180304-07-8
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
S-22153 是一种有效的褪黑素受体 (melatonin receptor) 拮抗剂，对 hMT1和 hMT2的EC50值分别为 19 nM 和 4.6 nM。S-22153 对 hMT1的Ki值为 8.6 nM (CHO 细胞) 和 16.3 nM (HEK 细胞)，hMT2的Ki值为 6.0 nM (CHO 细胞) 和 8.2 nM (HEK 细胞)。S-22153 是 MT1和 MT2褪黑素受体亚型的特异性配体。
生物活性

S-22153 is a potentmelatonin receptorantagonist withEC50values of 19 nM, 4.6 nM forhMT1andhMT2melatonin receptor, respectively. S-22153 hasKivalues of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1and MT2melatonin receptors subtypes[1][2].

IC50& Target[2]

MT1

19 nM (EC50)

MT2

4.6 nM (EC50)

体内研究
(In Vivo)

S-22153 sets the temperature and activity periods to approximately 24 hr and increase the circadian amplitude of both rhythms in mice, which exposed to continuous light[1].

Animal Model:7 weeks old Male B6D2F1 mice, which exposed to continuous light for 10-18 days[1]
Dosage:20 mg/kg
Administration:Daily intraperitoneal (i.p.) for 19 days
Result:Set the temperature and activity periods to approximately 24 hr and increased the circadian amplitude of both rhythms in mice, which exposed to continuous light.
分子量

247.36

Formula

C14H17NOS

CAS 号

180304-07-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.