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LY3027788
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY3027788图片
CAS NO:1377615-76-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LY3027788 是 LY3020371 的二酯类似物,是mGlu2/3 receptor的拮抗剂,是 LY3020371 的一种有效的口服活性前药。LY3027788 具有抗抑郁功效。
生物活性

LY3027788, a diester analog of LY3020371 which is anmGlu2/3 receptorantagonist, is a potent and orally active prodrug of LY3020371. LY3027788 has antidepressant efficacy[1][2].

IC50& Target

mGluR2

 

mGluR3

 

体内研究
(In Vivo)

LY3027788 (4.8-27 mg/kg; a single p.o.) produces antidepressant-like decreases in immobility times in the forced-swim test in mice[1].
LY3027788 (4.8-16 mg/kg; a single p.o.) enhances the locomotor stimulant effects of quinpirole at the dose of 16 mg/kg in the locomotor activity assay in mice[1].
LY3027788 (10-30 mg/kg; a single p.o.) dose dependently increases the wake time of rats without engendering rebound hypersomnolence[1].
LY3027788 (a single p.o.) leads to the rapid and dose-proportionate appearance of the pharmacologically active species LY3020371 in plasma of both mouse (4.8-27 mg/kg) and rat (3-30 mg/kg)[1].

Animal Model:Male Sprague-Dawley mice (20-25 g)[1]
Dosage:4.8, 16, 27 mg/kg
Administration:A single p.o. (60 minutes prior to testing)
Result:Potent and efficacious with a minimal effective dose of 16 mg/kg in the mouse forced-swim assay.
The ED60was 8.2 mg/kg.
分子量

591.58

Formula

C25H31F2NO11S

CAS 号

1377615-76-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.