DCG-IV

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DCG-IV

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

147782-19-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

DCG-IV 是一种有效的 II 类mGluRs受体激动剂，对 mGlu2R 和 mGlu3R 的EC₅₀值为 0.35 和 0.09 μM。DCG-IV 也是 I 组 (IC₅₀: mGlu1R/5R=389/630 μM) 和 III 组受体 (IC₅₀: mGlu4R/6R/7R/8R=22.5/39.6/40.1/32 μM) 的竞争性拮抗剂。DCG-IV 具有抗惊厥和神经保护作用。

生物活性

DCG-IV is a potent agonist of group IImGluRswithEC₅₀s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC₅₀: mGlu1R/5R=389/630 μM) and III receptors (IC₅₀: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects^[1]^[2].

IC₅₀& Target^[1]

mGluR2R

0.35 μM (EC₅₀)

mGluR3R

0.09 μM (EC₅₀)

mGluR1R

389 μM (IC₅₀)

mGluR5

630 μM (IC₅₀)

mGluR4R

22.5 μM (IC₅₀)

mGluR6

39.6 μM (IC₅₀)

mGluR7

40.1 μM (IC₅₀)

mGluR8

32 μM (IC₅₀)

体外研究
(In Vitro)

DCG-IV is also an NMDA receptor agonist in the rat cortical slice^[3].

体内研究
(In Vivo)

DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion^[4].

Animal Model:	Male ICR mice weighing about 40 g (PCP-induced locomotor activity)^[4]
Dosage:	10, 5, or 1 mg/kg
Administration:	I.p.
Result:	Reduced spontaneous activities of the animals at 10 or 5 mg/kg.

分子量

203.15

Formula

C₇H₉NO₆

CAS 号

147782-19-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.